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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and it suppresses triglyceride biosynthesis through the farnesol pathway. It is also a click chemistry reagent, containing an Alkyne group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.
Potent and competitive inhibitor of squalene epoxidase (SE)
Suppresses triglyceride biosynthesis through the farnesol pathway
Functions as a click chemistry reagent
Contains an Alkyne group
Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
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Rosiglitazone maleate a member of the thiazolidinedione class of antihyperglycaemic agents is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR- ) with IC50 of 42 nM Rosiglitazone maleate also modulates TRP channels and induces autophagy Rosiglitazone prevents ferroptosis
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Cediranib maleate is a highly potent, orally available VEGFR inhibitor. It effectively inhibits VEGF-stimulated proliferation and KDR phosphorylation in human umbilical vein endothelial cells and reduces vessel sprouting in coculture models. In vivo, it ablates experimental angiogenesis and inhibits the growth of various human tumor xenografts.
Highly potent, orally available VEGFR inhibitor
Inhibits VEGF-stimulated proliferation and KDR phosphorylation
Reduces vessel area, length, and branching at subnanomolar concentrations
Ablates experimental angiogenesis
Inhibits growth of established human tumor xenografts
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Cipralisant maleate is a research-grade histamine H3 receptor ligand used in pharmacology and neuroscience research. It acts as a potent, selective H3 receptor antagonist in vivo and may display agonist activity in certain in vitro assays. The material is supplied as a high-purity solid and is intended for experimental use under appropriate laboratory conditions.
Potent, selective histamine H3 receptor ligand.
Suitable for in vitro and in vivo pharmacology studies.
High reported purity (≈99.8%).
Stable as a powder when stored under recommended cold conditions.
Available in small package sizes for research, including 1 mg.
White to off-white solid appearance.
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